Histamine H 4 receptor antagonism prevents the progression of diabetic nephropathy in male DBA2/J mice
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چکیده
منابع مشابه
Pyridoxal phosphate prevents progression of diabetic nephropathy.
BACKGROUND We have demonstrated that pyridoxal 5'-phosphate (PLP), an active form of vitamin B6, inhibits formation of advanced glycation end-products (AGEs) by trapping 3-deoxyglucosone. The present study aimed to clarify if PLP could exert beneficial effects on nephropathy in diabetic rats. METHODS Streptozotocin (STZ)-induced diabetic rats were treated by oral administration of PLP or pyri...
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Diabetic nephropathy is one of the most severe diabetic microangiopathies and accounting for approximately one-third of all cases of end-stage renal disease. In the present study, we investigated the effect of mangiferin, a polyphenol from Anemarrhena asphodeloides Bge. or Mangifera indica L., on diabetic nephropathy and the possible mechanisms by using a developed diabetic nephropathy rat mode...
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BACKGROUND The protective effects of granulocyte colony-stimulating factor (G-CSF) have been demonstrated in a variety of renal disease models. However, the influence of G-CSF on diabetic nephropathy (DN) remains to be examined. In this study, we investigated the effect of G-CSF on DN and its possible mechanisms in a rat model. METHODS Otsuka Long-Evans Tokushima Fatty (OLETF) rats with early...
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The growth hormone (GH)/insulin-like growth factor (IGF) axis is involved in diabetic renal disease. The role of a specific GH receptor (GHR) antagonist in the development of early renal changes in nonobese diabetic (NOD) mice was investigated. Female diabetic (nonketotic) NOD mice treated with a polyethylene glycol-treated GHR antagonist (2 mg/kg, every other day) (DA group) or saline (D group...
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The aim of the study was to clarify whether antihypertensive treatment with a selective beta blocker would have an effect on the progression rate of kidney disease in patients with incipient diabetic nephropathy. Six male patients with juvenile-onset diabetes with incipient nephropathy (urinary albumin excretion above 15 /ig/min and total protein excretion below 0.5 g/24 hr) were treated with m...
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ژورنال
عنوان ژورنال: Pharmacological Research
سال: 2018
ISSN: 1043-6618
DOI: 10.1016/j.phrs.2018.01.002